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KMID : 0043319990220040417
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Archives of Pharmacal Research
1999 Volume.22 No. 4 p.417 ~ p.422
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Two New Lignans from Lindera obtusiloba Blume
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Kwon Hak-Cheol
Choi Sang-Un
Lee Jung-Ock
Bae Ki-Hwan
Zee Ok-Pyo
Lee Kang-Ro
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Abstract
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Two new furanolignans (3, 5), together with three known lignans (1, 2, 4,), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and -O-trans-feruloyl-5,51-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with .
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KEYWORD
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Lindera obtusiloba, Lauraceae, Cytotoxicity, Lignan, Actifolin, Pulviatilol
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